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Updated: Aug 6, 2026
09:58
A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
Published on: January 31, 2012
Heberden Oration 1981: epidemiology and the arthritides
Annals of the Rheumatic Diseases
|August 1, 1982
Summary
Osteoarthritis presents differently across various joints and sexes, with obesity linked to hand and knee involvement. These epidemiological findings challenge the idea of generalized osteoarthritis as a single entity.
Area of Science:
- Epidemiology
- Rheumatology
- Osteoarthritis Research
Background:
- Serum uric acid levels are multifactorially controlled.
- Osteoarthritis (OA) exhibits varied clinical characteristics across different joint groups.
- The relationship between radiographic changes and pain in OA is inconsistent across joints and sexes.
Purpose of the Study:
- To explore the epidemiological principles related to osteoarthritis.
- To investigate the heterogeneity of generalized osteoarthritis.
- To examine variations in OA presentation by joint group and sex.
Main Methods:
- Epidemiological analysis of osteoarthritis.
- Examination of clinical characteristics and radiographic findings.
- Assessment of associations between obesity, joint involvement, sex, and age groups.
Main Results:
- Osteoarthritis clinical features differ significantly between joint groups.
- The correlation between X-ray findings and pain varies by joint and sex.
- Obesity is associated with hand and knee OA, but not hip or ankle OA.
- Osteoarthritis is more prevalent in females, but this varies by age group.
Conclusions:
- The observed variations suggest generalized osteoarthritis may not be a homogenous condition.
- Further epidemiological studies focusing on specific joint groups and hypotheses are warranted.
- Iconic models may aid in developing targeted research hypotheses for osteoarthritis heterogeneity.
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