Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mercury oxidation in vitro by ferric compounds

M Ogata, K Kenmotsu, N Hirota

    Archives of Toxicology
    |May 1, 1982
    PubMed
    Summary

    Certain ferric compounds, like catalase, can oxidize metallic mercury. This finding may explain mercury

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Investigation of SO<sub>3</sub> absorption line for in situ gas detection inside combustion plants using a 4-μm-band laser source.

    Applied optics·2016
    Same author

    Molded-glass optical element for focusing servos.

    Applied optics·2010
    Same author

    Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.

    The Journal of experimental medicine·2001
    Same author

    [A sporadic case of Charcot-Marie-Tooth disease type 1 A associated with a duplication in chromosome 17 p11.2-p12].

    No to hattatsu = Brain and development·1999
    Same author

    Picture of the month. Cutaneous lesions associated with isoleucine deficiency.

    Archives of pediatrics & adolescent medicine·1998
    Same author

    Somatosensory evoked potentials with a unilateral migration disorder of the cerebrum.

    Journal of child neurology·1998

    Area of Science:

    • Biochemistry
    • Environmental Science
    • Toxicology

    Background:

    • Metallic mercury (Hg(0)) is a toxic environmental pollutant.
    • Understanding mercury oxidation is crucial for its detoxification and remediation.
    • Ferric compounds play roles in biological redox reactions.

    Purpose of the Study:

    • To investigate the ability of various ferric compounds to oxidize metallic mercury.
    • To explore the role of catalase and its active center, hematin, in mercury oxidation.
    • To correlate findings with mercury metabolism in vivo.

    Main Methods:

    • In vitro oxidation assays of metallic mercury using hydrogen peroxide.
    • Testing ferric compounds including cytochrome C, methemoglobin, lactoperoxidase, ferritin, catalase, and hematin.
    • Comparison with mercury uptake in acatalasemia mice.

    Main Results:

    • Catalase, cytochrome C, methemoglobin, lactoperoxidase, ferritin, and ferric ion oxidized metallic mercury in the presence of hydrogen peroxide.
    • Hematin, the active center of catalase, did not exhibit mercury oxidizing activity.
    • Results align with increased mercury oxidation and liver uptake observed in acatalasemia mice.

    Conclusions:

    • Specific ferric compounds, notably catalase, possess the enzymatic capability to oxidize metallic mercury.
    • The active center of catalase (hematin) alone is insufficient for mercury oxidation.
    • These findings provide insights into biological mercury detoxification mechanisms and the implications of catalase deficiency.

    Related Experiment Videos