[Microcirculatory bed in chronic arterial obliteration]

The state of tissue vessels in the skin, subcutaneous fat, fasciae and muscles of the lower extremities has been studied at various levels in 10 patients suffering from endarteritis and in 23 patients suffering from atherosclerosis. Certain morphological changes manifested have been revealed in small arteries, arterioles and capillaries: thickening of the muscle tunic, twisting, obliteration of small arteries, arteriolar narrowing, a sharp thickening of the precapillary sphincters, deformity and narrowing of the capillaries, their complete occlusion and fragmentation. The increasing destruction of the tissue vessels towards the periphery, when the disease advances further, results in the microvascular bed reduction with formation of vast avascular zones in distal segments of the extremities. Therefore, it is necessary to decide whether the agents capable to produce regeneration of the destroyed vascular elements should be used. The microvessel regeneration phenomenon can be stimulated by means of repeated infiltration of soft tissues in the injured extremities with the whole autoblood. In places where extravasates are situated, produced in this way, a corresponding reaction of the interstitium takes place, a loose connective tissue rich in organic vessels, such as small arteries, arterioles and capillaries, is formed and, as a result, the ischemic syndrome intensity decreases.