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Population-based reference values for lecithin-cholesterol acyltransferase (LCAT)

J J Albers, R O Bergelin, J L Adolphson

    Atherosclerosis
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Women have higher lecithin-cholesterol acyltransferase (LCAT) levels than men. LCAT mass correlates with body mass, cholesterol levels, and smoking habits in adults.

    Area of Science:

    • Biochemistry
    • Cardiovascular Health
    • Clinical Chemistry

    Background:

    • Lecithin-cholesterol acyltransferase (LCAT) is crucial for plasma cholesterol esterification.
    • Understanding LCAT levels in a general population is vital for assessing cardiovascular risk factors.

    Purpose of the Study:

    • To measure plasma LCAT levels in an adult employee population.
    • To investigate the association of LCAT levels with demographic and lifestyle factors.

    Main Methods:

    • Plasma LCAT mass was quantified using a sensitive double antibody radioimmunoassay.
    • A population sample of 237 adults (ages 20-59) from the Pacific Northwest was analyzed.
    • Statistical analyses were performed to correlate LCAT levels with age, sex, body mass, cholesterol, smoking, and alcohol consumption.

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    Main Results:

    • Women exhibited significantly higher LCAT levels than men after adjusting for body mass.
    • LCAT levels showed a slight positive correlation with age, relative body mass, total cholesterol, and LDL cholesterol.
    • Male smokers had significantly lower LCAT mass compared to non-smokers; no difference was observed between drinkers and non-drinkers.

    Conclusions:

    • Plasma LCAT levels vary by sex and are influenced by body mass, cholesterol profile, and smoking status.
    • Reference ranges for LCAT mass were established, with significantly lower levels observed in LCAT-deficient individuals and heterozygotes.