Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ocular changes resulting from therapy with amiodarone

D V Ingram, N S Jaggarao, D A Chamberlain

    The British Journal of Ophthalmology
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    trans-2-Nonenal insect repellent, insecticide, and flavor compound in carrot roots, cell suspensions, and "hairy" root cultures.

    Journal of chemical ecology·2013
    Same author

    pEmu: an improved promoter for gene expression in cereal cells.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Coronary care: home or hospital.

    Proceedings of the Royal Society of Medicine·2010
    Same author

    Bilateral Upper Thoracic Sympathectomy in Angina Pectoris: Results in 52 Cases.

    British medical journal·2010
    Same author

    A national scheme for public access defibrillation in England and Wales: early results.

    Resuscitation·2008
    Same author

    Interventional versus conservative treatment in acute non-ST elevation coronary syndrome: time course of patient management and disease events over one year in the RITA 3 trial.

    Heart (British Cardiac Society)·2006
    Same journal

    Reference map of multimodal vision deficits in intermediate age-related macular degeneration: contrast sensitivity and low-contrast visual acuity.

    The British journal of ophthalmology·2026
    Same journal

    Commentary on 'identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning'.

    The British journal of ophthalmology·2026
    Same journal

    Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

    The British journal of ophthalmology·2026
    Same journal

    Bacterial keratitis: a global review of current practices, challenges and innovations.

    The British journal of ophthalmology·2026
    Same journal

    Real-world integration of an autonomous artificial intelligence system for diabetic retinopathy screening in an endocrinology outpatient clinic.

    The British journal of ophthalmology·2026
    Same journal

    Maternal smoking during pregnancy: a risk factor for early childhood ophthalmologic conditions.

    The British journal of ophthalmology·2026
    See all related articles

    Amiodarone (antiarrhythmic drug) commonly causes corneal changes in 98% of patients. However, these changes are typically stable, reversible, and rarely cause symptoms, suggesting ophthalmological surveillance may not be mandatory for asymptomatic individuals.

    Area of Science:

    • Ophthalmology
    • Cardiology
    • Pharmacology

    Background:

    • Amiodarone is a potent antiarrhythmic medication.
    • Corneal changes are a known side effect of amiodarone.
    • The clinical significance of amiodarone-induced corneal changes remains debated.

    Purpose of the Study:

    • To investigate the prevalence and clinical implications of corneal changes in patients treated with amiodarone.
    • To assess the reversibility and long-term effects of these ocular abnormalities.

    Main Methods:

    • Serial slit-lamp examinations were performed on 105 patients receiving amiodarone.
    • Patients were observed for periods ranging from 3 months to over 7 years.
    • Corneal changes were monitored in relation to drug dosage and treatment duration.

    Related Experiment Videos

    Main Results:

    • Corneal abnormalities were detected in 103 patients (98%).
    • These changes typically progressed initially, then stabilized, and were dose-dependent.
    • Abnormalities regressed within 7 months after treatment cessation; no permanent sequelae were observed.
    • Ocular symptoms were infrequent, affecting only a small percentage of patients.

    Conclusions:

    • Amiodarone frequently induces corneal changes, but these are generally asymptomatic and reversible.
    • Ophthalmological surveillance may not be essential for asymptomatic patients on long-term amiodarone therapy.
    • The clinical impact of amiodarone-related corneal findings appears minimal in the absence of symptoms.