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Related Experiment Videos

Fibrinogen clearance from alveoli

E C Meyer, R Ottaviano, J J Higgins

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |October 1, 1978
    PubMed
    Summary

    Fibrinogen clearance from lung alveoli involves degradation into small molecules and bulk flow. This process primarily occurs within the distal airways, not the lung interstitium.

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    Area of Science:

    • Pulmonary Physiology
    • Biochemistry

    Background:

    • Fibrinogen is a key protein in blood coagulation.
    • Understanding its fate within the lungs is crucial for respiratory health.

    Purpose of the Study:

    • To investigate the clearance mechanisms of fibrinogen from the distal lung units.
    • To determine the location and kinetics of fibrinogen degradation within the lungs.

    Main Methods:

    • Instillation of radiolabeled fibrinogen (125I-fibrinogen) into canine alveoli.
    • Monitoring clearance using external detectors and blood/lymph sampling.
    • Comparison with intravenously injected radiolabeled fibrinogen (131I-fibrinogen).

    Main Results:

    • Approximately 9% of instilled fibrinogen entered proximal airways.
    • Whole lung clearance occurred via degradation to small molecules distributed in extracellular water.
    • Degradation was localized to distal airways, not the lung interstitium.
    • Intra-alveolar fibrinogen kinetics followed a 1.5 reaction order.

    Conclusions:

    • Fibrinogen clearance from alveoli involves both transbronchial bulk flow and intra-alveolar degradation.
    • Degradation primarily occurs within the distal airways.

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