Scanning electron microscopy of the metal-tissue interface. II. Observations with lead, copper, nickel, aluminium,...

The nature of the metal-tissue interface following the implantation of five pure metals, lead, copper, nickel, aluminium and cobalt, in rats has been observed by scanning electron microscopy. The general conclusion, derived from light microscopy that the tissue response to pure metals is characteristic of and specific to individual pure metals has been confirmed in this study. However, far more detailed observations of factors such as the extent of metallic corrosion, the distribution of red blood cells, platelets and other cells in the capsule and adherent to the metal surface, have been possible with SEM.