[Dispersion analysis used for assessing the anticonvulsant activity of 1,4-benzodiazepines]

A study was made of the time course of alterations in the convulsant activity of corazol after injection to mice of 1,4-benzodiazepine derivatives with different chemical structure. Significant anticonvulsant effect of benzodiazepines was observed for 5--120 minutes and was regarded a dynamic index. The maximal action of the drugs was observed within 15--30 minutes. The most pronounced anticonvulsant action was recorded after administering phenazepam and its 3-hydroxyderivative. The dependence of the anticonvulsant effect on the time of experiment and structure of the test compounds was examined by single-factor analysis of variance. The results demonstrate the relationship of differences in the anticonvulsant effects to the time factor and differences in the structure of the test compounds.