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Absorption of controlled-release iron

J D Cook, D A Lipschitz, B S Skikne

    Clinical Pharmacology and Therapeutics
    |October 1, 1982
    PubMed
    Summary
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    Controlled-release (CR) iron capsules showed superior absorption compared to elixirs when taken with meals. This finding suggests CR iron may be more effective for patients experiencing gastrointestinal side effects.

    Area of Science:

    • Nutritional Science
    • Pharmacokinetics
    • Gastroenterology

    Background:

    • Oral iron supplementation is common for iron deficiency anemia.
    • Iron absorption can be significantly affected by food intake.
    • Different iron formulations may have varying absorption profiles.

    Purpose of the Study:

    • To compare the iron absorption of a controlled-release (CR) capsule versus an elixir formulation.
    • To evaluate the impact of meals on the relative absorption of CR iron and elixir.
    • To determine the therapeutic potential of CR iron for patients experiencing side effects with oral iron.

    Main Methods:

    • A multiple-dose radioiron technique was employed in normal subjects.
    • Iron absorption was measured for both CR capsules and elixir (50 mg elemental iron as ferrous sulfate).

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  • Absorption was assessed in both fasting states and with meals of varying inhibitory potential.

    • Main Results:

    • In the fasting state, mean absorption was 4.92% for elixir and 4.38% for CR capsule (ratio 0.89, not significant).
    • With a mildly inhibitory meal, CR capsule absorption was 1.70 times that of the elixir.
    • With a more markedly inhibitory meal, CR capsule absorption was 3.13 times that of the elixir.

    Conclusions:

    • Controlled-release iron formulations demonstrate superior absorption compared to elixirs when administered with meals.
    • CR iron may offer a therapeutic advantage for patients who take oral iron with food to mitigate gastrointestinal distress.
    • The study highlights the importance of formulation in oral iron therapy, especially in the context of mealtime administration.