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Related Experiment Videos

Marked stress hyperglycemia in a child

B Chernow, T G Rainey, R Heller

    Critical Care Medicine
    |October 1, 1982
    PubMed
    Summary

    Severe stress hyperglycemia, a significant increase in blood glucose, was observed in a 16-month-old child experiencing respiratory distress. This condition, linked to elevated cortisol, reached unprecedented levels, highlighting a unique pediatric case.

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    Area of Science:

    • Pediatric Endocrinology
    • Critical Care Medicine
    • Metabolic Disorders

    Background:

    • Stress hyperglycemia is a transient increase in blood glucose levels due to acute illness or injury.
    • Elevated cortisol levels are known to contribute to hyperglycemia.
    • Pediatric cases of severe stress hyperglycemia are less commonly reported.

    Observation:

    • A 16-month-old child presented with respiratory distress syndrome.
    • The child experienced a rapid and severe fluctuation in serum glucose, from 74 mg/dl to 520 mg/dl within 24 hours.
    • Plasma cortisol levels mirrored glucose variations, rising from 41 to 90 mcg/dl.

    Findings:

    • The patient developed severe stress hyperglycemia, with glucose levels exceeding 350 mg/dl, a previously unreported severity in pediatric or adult cases.

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  • No intravenous dextrose or exogenous insulin was administered.
  • The hyperglycemia resolved spontaneously within 24 hours.

    • Implications:

    • This case expands the understanding of the potential severity of stress hyperglycemia in young children.
    • It underscores the critical role of stress hormones like cortisol in pediatric metabolic responses to critical illness.
    • Further research into the mechanisms and management of severe stress hyperglycemia in pediatrics is warranted.