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Circadian temporal structure in psoriasis

A Radaelli, F Carandente, G Tadini

    Chronobiologia
    |April 1, 1982
    PubMed
    Summary
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    Psoriasis disrupts the body's natural daily rhythms. This study found that circadian rhythms in psoriasis patients are altered and desynchronized, suggesting the condition affects more than just the skin.

    Area of Science:

    • Chronobiology
    • Dermatology
    • Internal Medicine

    Background:

    • Psoriasis pathogenesis remains unclear, with unpredictable disease courses despite treatments.
    • Altered epidermal cell turnover in psoriasis suggests potential disruption of skin's cellular rhythms.
    • Identifying disease-correlated parameters could improve patient definition and treatment.

    Purpose of the Study:

    • To investigate alterations in the circadian temporal structure of psoriasis.
    • To compare circadian rhythms of physiological variables in psoriatic patients versus healthy controls.

    Main Methods:

    • Studied easily detectable variables at 3-hour intervals in psoriatic and healthy subjects.
    • Monitored oral temperature, blood pressure, pulse, electrolytes, 17KS, 17-OHCS, and uricemia.

    Related Experiment Videos

  • Analyzed the reproducibility and synchronization of circadian rhythms within groups.

    • Main Results:

    • Healthy controls exhibited significant circadian rhythms for all measured variables.
    • Psoriatic patients showed few reproducible circadian rhythms.
    • When present, patient rhythms had different acrophases and were desynchronized within the group.

    Conclusions:

    • Psoriasis is associated with significant alterations in circadian rhythms.
    • The disease impacts systemic circadian structure, not solely the epidermis.
    • The etiology of psoriasis may involve broader disruptions beyond skin-specific mechanisms.