Haloperidol teratogenicity in the fetal hamster

Haloperidol, administered as a single intraperitoneal injection on day 8 of gestation, produced a variety of fetal malformations in hamsters. Fetal defects included exencephaly, cranioschisis, microphthalmia, anophthalmia, lower body hypodevelopment, and total body hypodevelopment. A dose-response relationship was evident as 80-245 mg/kg produced from 3 to 70% fetal anomalies.