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Polymer modification and blood compatibility

J M Courtney, G B Park, C R Prentice

    Journal of Bioengineering
    |June 1, 1978
    PubMed
    Summary
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    Researchers explored two methods to improve blood compatibility of methacrylate copolymers. Enhancing copolymer hydrophilicity and heparin treatment significantly improved blood compatibility, crucial for medical devices.

    Area of Science:

    • Biomaterials Science
    • Polymer Chemistry
    • Medical Device Engineering

    Background:

    • Copolymers of dimethylaminoethyl methacrylate are used in biomedical applications.
    • Blood compatibility is a critical factor for medical devices interacting with blood.
    • Existing materials may require surface modification to enhance hemocompatibility.

    Purpose of the Study:

    • To investigate methods for improving the blood compatibility of dimethylaminoethyl methacrylate-based copolymers.
    • To assess the impact of heparin treatment and ethylene oxide modification on copolymer hemocompatibility.
    • To establish relationships between material properties (composition, hydrophilicity) and blood clotting time.

    Main Methods:

    • Assessing blood compatibility using the recalcification time of platelet-rich plasma.

    Related Experiment Videos

  • Modifying copolymers of dimethylaminoethyl methacrylate and methyl methacrylate with heparin.
  • Altering the hydrophilicity of copolymers of dimethylaminoethyl methacrylate and acrylonitrile via ethylene oxide gas treatment.
  • Correlating exposure time to ethylene oxide gas with changes in clotting time.

    • Main Results:

    • Heparin treatment improved blood compatibility of dimethylaminoethyl methacrylate/methyl methacrylate copolymers, dependent on composition and polymerization method.
    • Ethylene oxide treatment altered copolymer hydrophilicity, influencing blood compatibility.
    • Increased exposure to ethylene oxide gas correlated with improved clotting time, indicating enhanced compatibility.
    • Hydrophilicity was identified as a key factor in the blood compatibility of modified copolymers.

    Conclusions:

    • Surface modification strategies, including heparinization and hydrophilicity alteration, can significantly enhance the blood compatibility of methacrylate copolymers.
    • The effectiveness of heparin treatment is influenced by copolymer composition and synthesis method.
    • Ethylene oxide modification offers a tunable approach to improve hemocompatibility by controlling hydrophilicity.
    • These findings are vital for developing safer and more effective blood-contacting medical devices.