Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental myringoplasty

R Baarsma, J Feijen, J Houthoff

    Journal of Bioengineering
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Heterologous collagen and amnion implants showed the best results for myringoplasty in rats, outperforming other materials like proplast and homologous collagen in healing tympanic membrane perforations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tensile properties of segmented block copolymers with monodisperse hard segments.

    Journal of materials science·2021
    Same author

    Structure formation and hydrogen bonding in all-aliphatic segmented copolymers with uniform hard segments.

    Acta biomaterialia·2012
    Same author

    Flexible, elastic and tear-resistant networks prepared by photo-crosslinking poly(trimethylene carbonate) macromers.

    Acta biomaterialia·2012
    Same author

    High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo.

    European cells & materials·2012
    Same author

    Micromechanical analysis of native and cross-linked collagen type I fibrils supports the existence of microfibrils.

    Journal of the mechanical behavior of biomedical materials·2012
    Same author

    Tissue engineering of small-diameter vascular grafts: a literature review.

    Clinical hemorheology and microcirculation·2012
    Same journal

    An accurate data collection method for spatial motion using a sonic digitizer.

    Journal of bioengineering·1978
    Same journal

    A model for evaluating the ocular contusion injury potential of propelled objects.

    Journal of bioengineering·1978
    Same journal

    The wear behavior of vacuum-vapor-deposited carbon films.

    Journal of bioengineering·1978
    Same journal

    Tissue ingrowth in porous acrylic cement.

    Journal of bioengineering·1978
    Same journal

    In vitro cytotoxicity and in vivo acute responses to some amino acid copolymers and their esters.

    Journal of bioengineering·1978
    Same journal

    The thrombogenicity of radiation grafted polymers as measured by the vena cava ring test.

    Journal of bioengineering·1978
    See all related articles

    Area of Science:

    • Otolaryngology
    • Biomaterials Science
    • Regenerative Medicine

    Background:

    • Tympanic membrane perforations are common clinical issues.
    • Myringoplasty is a surgical procedure to repair these perforations.
    • Evaluating novel biomaterials for myringoplasty is crucial for improving surgical outcomes.

    Purpose of the Study:

    • To compare the efficacy of various implant materials in rat myringoplasty models.
    • To assess the long-term structural and histological integration of different biomaterials.

    Main Methods:

    • Myringoplasty was performed on rats using autologous fascia, homologous tympanic membrane, homologous collagen, heterologous collagen, heterologous amnion, and proplast.
    • A control group with perforated eardrums but no repair was included.

    Related Experiment Videos

  • Animals were observed for 40 and 64 weeks, with macroscopic and microscopic examinations.

    • Main Results:

    • Proplast and homologous collagen showed inferior results compared to homograft tympanic membrane and autologous fascia.
    • Heterologous collagen and heterologous amnion demonstrated superior macroscopic and histological outcomes.
    • These materials facilitated better healing and integration in the myringoplasty model.

    Conclusions:

    • Heterologous collagen and heterologous amnion are promising biomaterials for myringoplasty.
    • These materials offer significant advantages over traditional grafts and synthetic implants.
    • Further research may validate their use in human clinical applications for tympanic membrane repair.