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Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
Published on: September 26, 2014
Effect of polyurethane morphology on blood coagulation
Journal of Bioengineering
|June 1, 1978
Summary
Polyurethane
Area of Science:
- Polymer Science
- Biomaterials
Background:
- Polyurethanes are versatile polymers with tunable properties.
- Phase separation in polyurethanes influences their biological interactions.
Purpose of the Study:
- To investigate the impact of fabrication-induced structural order on polyurethane properties.
- To correlate material structure with the activation of intrinsic blood coagulation pathways and platelet adhesion.
Main Methods:
- Synthesis of polyurethanes using MDI, PTMG (varying molecular weights), and ethylene diamine.
- Fabrication techniques to achieve maximum disorder (quenched) and maximum order (annealed) states.
- Assessment of factor XII activation and platelet attachment.
Main Results:
- The quenched, non-equilibrium state significantly reduced factor XII pathway activation compared to the annealed state.
- Platelet attachment was predominantly influenced by the degree of phase separation within the polyurethanes.
Conclusions:
- Material processing and resulting structural order critically affect the thrombogenicity of polyurethanes.
- Phase separation is a key determinant of platelet interactions with these biomaterials.
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