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[Benzenedithiol esters with antimycotic activity]

F Pavanetto, L Montanari, T Modena

    Il Farmaco; Edizione Scientifica
    |June 1, 1982
    PubMed
    Summary

    New antifungal compounds derived from benzen-1,2-dithiol show significant antimycotic activity against common fungal strains. These novel diesters demonstrate potent fungistatic effects, outperforming clotrimazole in vitro.

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    Area of Science:

    • Medicinal Chemistry
    • Organic Synthesis
    • Mycology

    Context:

    • Antifungal resistance necessitates the development of novel therapeutic agents.
    • Benzenedithiols are versatile precursors for synthesizing compounds with potential biological activity.
    • Existing antifungal treatments face challenges with efficacy and resistance.

    Purpose:

    • To synthesize and evaluate the in vitro antifungal activity of novel diesters derived from benzen-1,2-dithiol.
    • To compare the antimycotic efficacy of these synthesized compounds against standard antifungal drugs.
    • To investigate the structure-activity relationship of benzenedithiol derivatives against pathogenic fungi.

    Summary:

    • Diesters of benzen-1,2-dithiol with aliphatic and aromatic carboxylic acids were synthesized via condensation reactions.
    • In vitro antifungal activity was assessed against Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, and Trichophyton mentagrophytes.
    • Diesters of benzen-1,2-dithiol with alkanoic acids exhibited marked fungistatic activity, surpassing clotrimazole in potency.

    Impact:

    • Identified potent novel antifungal agents with potential for further development.
    • Provides a basis for designing more effective antimycotic therapies.
    • Highlights the therapeutic potential of benzen-1,2-dithiol derivatives in combating fungal infections.

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