Experimental anastomosis of the rabbit fallopian tube using fibrin glue

Experimental end-to-end anastomosis was performed in 20 rabbits with biologic tissue adhesive allogenic fibrinogen, after removal of 1 to 2 cm of the isthmus. A standardized insemination procedure was undertaken to achieve pregnancies in the animals upon which operations were performed. Without any intervention, the fertility rate was 80% after repeated inseminations in ten nonexperimental rabbits. After anastomosis of the fallopian tube using fibrin glue, the patency rate was 75% (30 of 40 fallopian tubes), and the subsequent pregnancy rate was 60% (12 of 20 animals). No spontaneous recanalization nor subsequent pregnancy was observed in the control group after removal. Histologic findings demonstrated mild to moderate tissue reactions, comparable to those observed when microsutures were used.