Bioavailability study on a new slow-release formulation of ketoprofen

Area of Science:

• Pharmacokinetics
• Drug formulation
• Clinical pharmacology

Background:

• Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.
• Optimizing ketoprofen delivery can improve patient compliance and therapeutic outcomes.
• Evaluating novel drug delivery systems is crucial for enhancing pharmaceutical efficacy.

Purpose of the Study:

• To compare the bioavailability of new slow-release ketoprofen capsules against standard plain capsules.
• To assess the rate and extent of ketoprofen absorption from different formulations.
• To determine the suitability of slow-release ketoprofen for reduced dosing frequency.

Main Methods:

• A crossover bioavailability study involving four healthy adult subjects.
• Administration of two ketoprofen formulations: plain capsules (50 mg t.i.d.) and slow-release capsules (150 mg b.i.d.).
• Assessment of plasma ketoprofen levels using gas-liquid chromatography (GLC) on the fourth day of each treatment period.

Main Results:

• Absorption from slow-release ketoprofen capsules was observed to be slower and more sustained.
• The extent of absorption from the slow-release formulation was nearly complete.
• Plasma concentration profiles indicated a prolonged drug release pattern for the slow-release capsules.

Conclusions:

• The new slow-release ketoprofen capsules demonstrate favorable bioavailability characteristics.
• The formulation supports a reduced frequency of daily dosing, enhancing convenience.
• Slow-release ketoprofen shows potential for effective clinical application in managing pain and inflammation.