Effect of vitamin B2 on tumorigenesis of 3-methylcholanthrene in the mouse skin

Local administration of riboflavin 2',3',4',5'-tetrabutyrate (B2-But4) suppressed the induction of skin tumors in mice by 3-methylcholanthrene. The latent period for the appearance of tumors was markedly delayed in the group treated with B2-But4. These findings suggest that riboflavin might retard the process of skin tumorigenesis.