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Related Experiment Videos

Ulcerating enteritis associated with flucytosine therapy

C A White, J Traube

    Gastroenterology
    |November 1, 1982
    PubMed
    Summary
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    Reply to Jiang et al.

    Gastroenterology·2026
    See all related articles

    Flucytosine can cause severe enteritis, a serious gastrointestinal condition. This case highlights the importance of diagnostic imaging and biopsy in identifying this rare but potentially fatal side effect.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Internal Medicine

    Background:

    • Flucytosine is an antifungal medication.
    • Diarrhea is a known side effect of flucytosine.
    • Ulcerating enterocolitis is a rare but severe complication.

    Observation:

    • A patient developed severe gastrointestinal symptoms while on flucytosine.
    • Radiologic imaging showed significant abnormalities in the small bowel.
    • Ileal biopsy confirmed erosive enteritis.

    Findings:

    • The patient's symptoms and imaging findings were consistent with flucytosine-associated ulcerating enteritis.
    • Radiologic findings included luminal narrowing, ulceration, and bowel loop separation.
    • Pathologic findings revealed mucosal inflammation and epithelial disruption.

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    Implications:

    • This case underscores the need for vigilant monitoring of patients receiving flucytosine.
    • Diagnostic imaging and biopsy are crucial for identifying flucytosine-induced enteritis.
    • Discontinuation of flucytosine led to complete resolution of symptoms and abnormalities.