Related Experiment Video
Updated: Jul 15, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Gut hormone release after intestinal resection
Gut
|October 1, 1982
Summary
Gut resection alters gut and pancreatic hormones. Ileal resection significantly increased pancreatic polypeptide, motilin, gastrin, and enteroglucagon. Colonic resection only increased pancreatic polypeptide, suggesting hormonal roles in adaptation.
Area of Science:
- Gastroenterology
- Endocrinology
- Surgical Research
Background:
- Gut resection can lead to significant physiological adaptations.
- The role of gastrointestinal and pancreatic hormones in these adaptive responses is not fully understood.
Purpose of the Study:
- To investigate the role of gut and pancreatic hormones in adaptive responses following intestinal resection.
- To compare hormonal changes in patients with small intestinal resection versus colonic resection.
Main Methods:
- Plasma concentrations of circulating hormones were measured in response to a test breakfast.
- Study included patients with partial ileal resection, colonic resection, and healthy control subjects.
Main Results:
- Patients with ileal resection showed significant increases in pancreatic polypeptide, motilin, gastrin, and enteroglucagon levels compared to controls.
- Patients with colonic resection exhibited a significant rise in pancreatic polypeptide levels only.
- Hormonal changes varied based on the location of intestinal resection.
Conclusions:
- Specific gut and pancreatic hormones, including pancreatic polypeptide, motilin, gastrin, and enteroglucagon, may play a role in the adaptive changes observed after gut resection.
- The observed hormonal alterations suggest a potential mechanism for post-resection adaptation, particularly after small bowel resection.
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