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Amoxapine-associated rhabdomyolysis and acute renal failure: case report
Abstract:
Amoxapine, a new tricyclic antidepressant, has been recently released in the United States and Europe. There has been limited experience with amoxapine overdose, and no serious reactions or sequelae were observed in the reported cases. A case of amoxapine overdose associated with rhabdomyolysis and acute renal failure is reported. Amoxapine overdose could cause convulsions or prolonged coma leading to atraumatic rhabdomyolysis and myoglobinuric renal failure. Direct muscle or renal toxicity from this drug and its metabolites should not be excluded until evidence to the contrary is available. Acute renal failure should be looked for in cases of amoxapine overdose.
Insights
Amoxapine overdose can lead to rhabdomyolysis and acute kidney injury. Clinicians should monitor for these serious complications in patients with amoxapine toxicity.
Area of Science:
- Pharmacology
- Nephrology
- Toxicology
Background:
- Amoxapine is a tricyclic antidepressant recently approved in the US and Europe.
- Limited data exists on amoxapine overdose, with previous reports showing no severe outcomes.
Observation:
- A case of amoxapine overdose is presented.
- The overdose was associated with rhabdomyolysis and acute renal failure.
Findings:
- Amoxapine overdose can precipitate seizures or prolonged coma.
- These neurological effects may lead to atraumatic rhabdomyolysis and myoglobinuric acute renal failure.
Implications:
- Direct muscle or renal toxicity of amoxapine and its metabolites requires further investigation.
- Acute kidney injury should be actively screened for in amoxapine overdose cases.