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R-factor mediated trimethoprim resistance: result of two three-month clinical surveys
Abstract:
All urinary tract isolates were monitored in the Whittington Hospital, London for trimethoprim resistance over a three-month period in 1975; this survey was repeated 18 months later in 1977. In the later survey the incidence of trimethoprim resistance had increased significantly, and the proportion of strains carrying R-factors conferring trimethoprim resistance had nearly doubled. The pattern of resistances associated with R-factor trimethoprim resistance also changed betweeen these two surveys.
Insights
Trimethoprim resistance in urinary tract infections significantly increased between 1975 and 1977. The proportion of resistant strains carrying R-factors nearly doubled, indicating a concerning rise in antimicrobial resistance.
Area of Science:
- Medical Microbiology
- Antimicrobial Resistance
Background:
- Urinary tract infections (UTIs) are common bacterial infections.
- Trimethoprim has been a key antibiotic for treating UTIs.
- Monitoring antibiotic resistance is crucial for effective treatment.
Purpose of the Study:
- To assess trimethoprim resistance trends in urinary tract isolates.
- To determine changes in R-factor prevalence and associated resistance patterns.
Main Methods:
- Surveillance of urinary tract isolates at Whittington Hospital, London.
- Monitoring trimethoprim resistance over two distinct periods (1975 and 1977).
- Analysis of R-factor carriage and associated resistance.
Main Results:
- A significant increase in trimethoprim resistance was observed between 1975 and 1977.
- The proportion of strains with R-factors conferring trimethoprim resistance nearly doubled.
- Changes in the resistance patterns associated with R-factors were noted.
Conclusions:
- Trimethoprim resistance in UTIs escalated rapidly within an 18-month period.
- R-factors played a significant role in the observed increase of trimethoprim resistance.
- Evolving resistance patterns necessitate ongoing surveillance and treatment strategy review.