The effect of cigarette smoke on the tracheal mucosa of the rabbit. An electron microscopic study

The effect of whole cigarette smoke on the tracheal mucosa of the rabbit has been studied by the electron microscope. The epithelium shows oedema and disturbed stratification. The cilia are sparse and some show clubbing. The basal cells are active. Large amorphorous bodies and numerous vacuoles are found in the tunica propria. Some damage in the smooth muscles is found. The irritative effect of cigarette smoke on the epithelium is demonstrated. Factors which may explain the rare incidence of malignancy in the trachea are discussed.