Cyclocreatine phosphate, an analogue of creatine phosphate, does not improve hypoxic tolerance in mice

Dietary cyclocreatine has been reported to increase brain high-energy stores in mice and to prolong the generation and utilization of these stores following decapitation. A possible cerebral protective action after 50 days of dietary cyclocreatine 0.5 and 1.0% was therefore examined in mice. Cyclocreatine 0.5% did not increase survival time during hypoxia (5% O2). Cyclocreatine 1.0% in the absence of hypoxia caused significant mortality and decreased weight in survivors despite prophylactic antibiotic treatment. Dietary cyclocreatine offers no cerebral protection against hypoxia in mice.