Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Traumatic head injury and pulmonary damage

D J Crittenden, D L Beckman

    The Journal of Trauma
    |September 1, 1982
    PubMed
    Summary

    Mechanical head injury can cause lung complications. Studies show head trauma increases lung surface tension and cholesterol, especially in cats with seizures, suggesting altered alveolar lining.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vital involvement of a natural killer cell activation receptor in resistance to viral infection.

    Science (New York, N.Y.)·2001
    Same author

    Effects of peroxynitrite on pulmonary edema and the oxidative state.

    Experimental lung research·2000
    Same author

    Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin.

    Blood·1999
    Same author

    A thioreduction pathway tethered to the membrane for periplasmic cytochromes c biogenesis; in vitro and in vivo studies.

    Journal of molecular biology·1997
    Same author

    Molecular and immunological analysis of an ABC transporter complex required for cytochrome c biogenesis.

    Journal of molecular biology·1997
    Same author

    Effect of unweighting on skeletal muscle use during exercise.

    Journal of applied physiology (Bethesda, Md. : 1985)·1995

    Area of Science:

    • Pulmonary Medicine
    • Neurology
    • Biochemistry

    Background:

    • Head injuries can lead to pulmonary complications like edema and hyperemia.
    • Alveolar surfactant plays a crucial role in maintaining lung function.

    Purpose of the Study:

    • To investigate the biochemical changes in alveolar lavage following mechanical head injury.
    • To determine the role of lung surface tension, cholesterol, and phospholipids in head-injury-induced pulmonary complications.

    Main Methods:

    • Experimental induction of head injury in cats using a captive bolt.
    • Analysis of alveolar lavage fluid for surface tension, cholesterol, phospholipids, and protein.
    • Comparison between cats with and without immediate post-traumatic seizures.

    Main Results:

    • Head-injured cats with seizures showed significantly increased minimum surface tension and cholesterol levels.
    • The ratio of cholesterol to total phospholipids increased in head-injured cats with seizures.
    • Elevated lung wash protein was observed in both groups of head-injured cats.

    Conclusions:

    • Mechanical head injury, particularly with associated seizures, alters lung alveolar surfactant composition.
    • Changes in lung surface tension and cholesterol may contribute to pulmonary complications after head trauma.
    • Altered alveolar surface lining is implicated in the pathophysiology of head-injury-related lung dysfunction.

    Related Experiment Videos