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[Dehydration therapy in human exposure to simulated space flight factors]
Kosmicheskaia Biologiia I Aviakosmicheskaia Meditsina
|July 1, 1982
Summary
Intravenous mannitol infusions caused dehydration but improved heart function in healthy men during bed rest. This osmotherapy reduced cardiac workload and enhanced left ventricle performance without affecting central circulation.
Area of Science:
- Physiology
- Cardiovascular Medicine
- Pharmacology
Background:
- Bed rest can negatively impact cardiovascular function.
- Osmotherapy, using agents like mannitol, is explored for its physiological effects.
- Understanding mannitol's impact on circulation and cardiac function is crucial.
Purpose of the Study:
- To investigate the effects of intravenous mannitol on central circulation and cardiac contractile function.
- To assess the physiological responses during prolonged bed rest and recovery.
- To evaluate mannitol's role in mitigating bed rest-induced cardiovascular changes.
Main Methods:
- 18 healthy male volunteers underwent intravenous infusions of 20% mannitol (1 g/kg at 5 ml/min).
- Measurements were taken during a control period, on days 3, 7, and 14 of -8 degrees head-down tilt bed rest, and during recovery.
- Central circulation and cardiac contractile function were assessed.
Main Results:
- Mannitol induced a clinically significant dehydration effect.
- No adverse influence on central circulation was observed.
- Positive cardiodynamic changes indicated reduced cardiac workload and improved left ventricle function.
Conclusions:
- Prolonged osmotherapy with mannitol effectively causes dehydration.
- Mannitol administration positively impacts cardiac dynamics, enhancing left ventricle performance.
- Mannitol appears safe for central circulation during bed rest simulations.