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Determination of labetalol in a post mortem case using HPLC
Journal of Analytical Toxicology
|July 1, 1982
Summary
This case report details the detection of low labetalol levels in post-mortem biological samples. The findings are discussed in relation to a patient with a respiratory condition.
Area of Science:
- Forensic Toxicology
- Analytical Chemistry
Background:
- Labetalol is an antihypertensive medication.
- Accurate quantification of drug levels in post-mortem samples is crucial for forensic investigations.
Purpose of the Study:
- To report a case involving the analysis of post-mortem biological samples for labetalol.
- To discuss the significance of detected low labetalol concentrations in a patient with respiratory disease.
Main Methods:
- Post-mortem samples (stomach contents, liver, kidney, urine, blood) were analyzed.
- Labetalol was extracted using Sep-pakTM C18 cartridges after flocculation with aluminum hydroxide.
- Quantification was performed using High-Performance Liquid Chromatography (HPLC) with an ultraviolet detector.
Main Results:
- Relatively low levels of labetalol were detected in the analyzed post-mortem samples.
- The specific concentrations varied across different tissues and fluids.
Conclusions:
- The presence of low labetalol levels in this case warrants consideration, particularly in patients with underlying respiratory conditions.
- This case highlights the importance of comprehensive toxicological analysis in post-mortem investigations.