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Maprotiline fatality: case report and analytical determinations

T A Rejent, R E Doyle

    Journal of Analytical Toxicology
    |July 1, 1982
    PubMed
    Summary
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    Maprotiline hydrochloride, a tetracyclic antidepressant, was identified as the sole cause of death in a young adult following a massive overdose. This case highlights the potential toxicity of maprotiline in significant quantities.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Analytical Chemistry

    Background:

    • Maprotiline hydrochloride is a tetracyclic antidepressant used for treating depression.
    • Overdose cases involving antidepressants can present significant toxicological challenges.
    • Accurate analytical methods are crucial for identifying and quantifying drug levels in forensic investigations.

    Observation:

    • A fatal case involving a 23-year-old individual who ingested a massive dose (4.5-6.0 g) of maprotiline hydrochloride was reported.
    • This case is potentially the first documented death solely attributed to maprotiline in the United States.
    • Various analytical techniques, including chromatographic and spectrophotometric systems, were employed to study the drug's parameters.

    Findings:

    • Maprotiline hydrochloride was confirmed as the exclusive agent responsible for the fatality.

    Related Experiment Videos

  • Gas-liquid chromatography with a nitrogen-phosphorous detector was utilized for accurate quantitation of maprotiline.
  • Concentrations of maprotiline were determined in biological fluids and tissues of the subject.

    • Implications:

    • This case underscores the critical importance of therapeutic drug monitoring and overdose management for maprotiline.
    • The reported analytical methods provide valuable tools for forensic toxicology in similar cases.
    • Understanding the toxicokinetics and lethal dose of maprotiline is essential for clinical and forensic practice.