The effects of parasympathetic blocking agents on bladder electromyograms and function in conscious and anaesthetized...

Voiding induced in conscious cats by infusion of sterile saline into the bladder via a chronically implanted bladder catheter was stable over many months. Artefact-free recordings of electrical activity obtained from the bladder neck and dome of these preparations during bladder filling and voiding showed characteristic voiding electromyograms but did not permit a functional differentiation. Both voiding and the associated electromyogram were abolished by the ganglion blocking agent, pentolinium. Hyoscine or methyl atropine did not affect the electromyogram but impaired the ability of cats to empty their bladders completely. In anaesthetized cats, ganglion blocking agents prevented a rise in bladder pressure during sacral ventral root stimulation but a hyoscine-sensitive bladder contraction was seen following the period of stimulation. Further stimulation during this post-stimulus rise in intravesical pressure revealed a hyoscine-sensitive stimulus-bound relaxation. Sacral ventral root stimulation relaxed the bladder neck/proximal urethra particularly in the presence of sympathetic tone.