[Regulation of lung regeneration]

The materials on lung regeneration are generalized, the prerequisites for the stimulation of compensatory hypertrophy of the lung tissue are considered, the results of application of regeneration stimulators in the experimental and clinical conditions are first systematized and analyzed. Experiments were carried on over 3,500 animals with the use of complex morphometrical, biochemical, autoradiographical, morphological, cytochemical methods; the functional state of lung tissue was evaluated under the conditions of application of regeneration stimulators. The application of purines and pyrimidines contributes to a more complete and rapid development of compensatory hypertrophy of the lung, restoration of the total alveolar surface, leads to the formation of alveoli de novo, prevents the appearance of the phenomena of morphological and functional decompensation at remote times after the operation, excludes the development of pneumofibrosis. The mechanisms of the stimulating effect of the drugs in question on the development of compensatory hypertrophy of the lung are revealed, a new classification is proposed.