Synthesis of substituted benzamides and benzimidazoles as anthelmintic and antimicrobial agents

The synthesis and biological activity of a series of substituted benzamides (5-8, 14-17) 3,5-dinitrobenzoic acids (12, 13, 18) and benzimidazoles (9-11, 19-21) are described. Compounds 5, 6, 7, 12 and 14 showed 40-50% clearance of Nippostrongylus brasiliensis in rats at a dose of 250 mg/kg given daily for 3 d while a few compounds inhibited the growth of various strains of bacteria and fungi.