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Related Experiment Videos

Vasospasm control by intra-arterial reserpine

L N Hurst, H B Evans, D H Brown

    Plastic and Reconstructive Surgery
    |November 1, 1982
    PubMed
    Summary
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    A single intra-arterial injection of low-dose reserpine effectively treats vascular spasm by causing a prolonged sympathectomy. This method offers a safe and effective alternative to traditional treatments for conditions causing vasoconstriction.

    Area of Science:

    • Vascular Surgery
    • Pharmacology
    • Neuroscience

    Background:

    • Vascular spasm, resulting from trauma or disease, can lead to severe complications like thrombosis and tissue necrosis.
    • Current treatments, such as proximal sympathetic blocks, offer only transient relief and are poorly tolerated.
    • There is a need for effective, well-tolerated treatments for reversible vascular spasm.

    Purpose of the Study:

    • To evaluate the efficacy and safety of a single intra-arterial injection of low-dose reserpine for treating vascular spasm.
    • To assess the duration and extent of sympathectomy induced by intra-arterial reserpine.
    • To determine the side effects and complications associated with this treatment method.

    Main Methods:

    • A single intra-arterial injection of 1.25 mg of reserpine was administered into the brachial artery of human volunteers using a No. 25 needle.

    Related Experiment Videos

  • The study measured cutaneous flushing, increased temperature, digital pulse wave recordings, and response to cold stimulus.
  • The procedure aimed to induce a prolonged sympathectomy distal to the injection site.

    • Main Results:

    • A single intra-arterial reserpine injection produced a prolonged sympathectomy distal to the injection site.
    • Key indicators of successful sympathectomy included cutaneous flushing, increased temperature, and enhanced digital pulse wave recordings.
    • The treatment effectively eliminated vasoconstriction induced by cold stimuli, with minimal side effects and no procedural complications.

    Conclusions:

    • Low-dose intra-arterial reserpine is a safe and effective treatment for reversible vascular spasm.
    • This technique provides a prolonged sympathectomy, offering a promising alternative to less tolerated treatments.
    • The study recommends intra-arterial reserpine for managing conditions involving vascular spasm.