Species differences in hypocalcemia induced by acetyl-salicylic acid

The study was performed to explore species differences in hypocalcemia induced by acetylsalicylic acid (ASA). ASA decreased plasma and serum calcium (Ca) level at the dose of more than 200 mg/kg s.c. and p.o. in mouse, rat and guinea pig, and a correlation between serum Ca and salicylic (SA) levels was recognized in these species. However, hypocalcemia was not observed in rabbit and dog by the oral administration of ASA 400 mg/kg though high serum levels were found. Species differences were recognized in ASA-induced hypocalcemia. It was suggested that the differences were probably due to the different activity of calcitonin decreased serum Ca level in rabbit.