Pharmacological actions of diaspirins, potential antisickling agents I: A preliminary study

The acute toxicity (LD50) and effects on locomotor activity of three alternative aspirin analogs were determined in mice of both sexes. Dibromoaspirin, bis(dibromosalicyl) succinate and bis(dibromosalicyl) fumarate were administered in oral suspension. The 24-hour LD50 values in both male and female mice were within the same range as that of commercial aspirin (i.e., 1100 mg/kg). The effects of 1/40, 1/20, 1/10 and 1/5 LD50 doses of each compound were tested on locomotor activity of male mice. These compounds decreased locomotor activity in a dose-dependent fashion.