Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg<sup>D257A</sup> mutator mice.

Infection and immunity·2025

Same author

The acute management of Pilon fractures (ENFORCE) study: a national evaluation of practice.

Annals of the Royal College of Surgeons of England·2024

Same author

Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg<sup>D257A</sup> mutator mice.

bioRxiv : the preprint server for biology·2024

Same author

What is a tibial pilon fracture and how should they be acutely managed? A survey of consultant British Orthopaedic Foot and Ankle Society members and non-members.

Annals of the Royal College of Surgeons of England·2023

Same author

Reliable Initial Trauma CT Findings of Supraclavicular Brachial Plexus Injury in Patients Sustaining Blunt Injuries.

AJNR. American journal of neuroradiology·2023

Same author

Comments on the Feature "Potato Early Dying: Management Challenges in a Changing Production Environment".

Plant disease·2019

Search research articles

Related Experiment Video

Updated: Jul 24, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Utility of thyroid aspiration biopsy

L W Norton, S L Wangensteen, J R Davis

|October 1, 1982

Summary

Fine-needle aspiration biopsy effectively detects thyroid carcinoma, with accuracy varying by interpretation criteria. High negative predictive values suggest its utility in ruling out cancer.

Area of Science:

Endocrinology
Oncology
Surgical Pathology

Background:

Thyroid nodules are common, and accurate diagnosis is crucial for appropriate management.
Fine-needle aspiration biopsy (FNAB) is a primary diagnostic tool for thyroid nodules.
Evaluating the diagnostic performance of FNAB is essential for clinical decision-making.

Purpose of the Study:

To assess the diagnostic utility and performance metrics of fine-needle aspiration biopsy in detecting thyroid carcinoma.
To compare the accuracy, sensitivity, and specificity of FNAB based on different interpretation criteria.

Main Methods:

A decision-analysis approach was used to evaluate FNAB in 102 patients with thyroid nodules.
Cytologic diagnoses were categorized, and follow-up, including thyroidectomy, was performed.

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jul 24, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Diagnostic performance metrics (sensitivity, specificity, predictive values, accuracy) were calculated using two distinct interpretation criteria.

Main Results:

FNAB demonstrated no morbidity. Accuracy was highest (88%) when atypical results were not considered malignant (Criterion II).
Sensitivity was 70% and specificity 90% under Criterion II.
Negative predictive values were high (96-99%), while positive predictive values remained low (31-44%) regardless of the criterion used.

Conclusions:

The sensitivity and specificity of FNAB for thyroid carcinoma detection are dependent on the interpretation criteria applied.
FNAB is a valuable tool for thyroid nodule evaluation, particularly for excluding malignancy, when interpreted alongside clinical findings.
Optimizing interpretation criteria enhances the diagnostic accuracy of FNAB in thyroid cancer detection.