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Absorption of intraperitoneally injected amipaque in the rabbit
Acta Radiologica: Diagnosis
|January 1, 1982
Summary
Amipaque injected intraperitoneally rapidly clears the peritoneal cavity, demonstrating urinary tract filling within an hour. Minimal gastrointestinal absorption suggests bowel perforation if Amipaque appears in the peritoneal cavity or urinary tract after oral administration.
Area of Science:
- Radiology
- Pharmacokinetics
- Diagnostic Imaging
Background:
- Amipaque is a contrast agent used in diagnostic imaging.
- Understanding its absorption and distribution is crucial for interpreting imaging studies.
Purpose of the Study:
- To describe the appearance and absorption rate of intraperitoneally injected Amipaque.
- To establish criteria for identifying bowel perforation based on Amipaque's distribution.
Main Methods:
- Intraperitoneal injection of Amipaque in a study population.
- Serial imaging to observe Amipaque's distribution and concentration over time.
- Assessment of Amipaque's presence in the peritoneal cavity and urinary tract.
Main Results:
- Peritoneal concentration of Amipaque decreased significantly by 30 minutes post-injection.
- Urinary tract visualization began at 30 minutes and was well-demonstrated by one hour.
- Nearly complete clearance from the peritoneal cavity occurred within one hour.
Conclusions:
- Intraperitoneal Amipaque is rapidly absorbed and excreted via the urinary tract.
- The minimal absorption from the gastrointestinal tract implies that Amipaque in the peritoneal cavity or urinary tract after oral administration is a strong indicator of bowel perforation.