HLA antigens and growth in diabetic children

HLA types in 121 diabetic children in Newcastle are examined in relation to their growth records. The children's height at the onset of diabetes was normal, but fell away during the course of the disease; there was low mean height velocity and failure of bone development to keep pace with chronological age. The total series shows the expected excess of HLA antigens B8, B15 and Cw3 and deficit of B7. Children with B8 are of smaller stature adjusted for bone age than those without the antigen, while children with B7 appear to do better. The results suggest that within the diabetic spectrum of genotypes the HLA antigens are relevant to growth and development.