Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Phenobarbitone dosage in neonatal convulsions

R A Ouvrier, R Goldsmith

Archives of Disease in Childhood

|September 1, 1982

Summary

This summary is machine-generated.

Finding the optimal phenobarbitone dosage for neonatal convulsions is crucial. A loading dose of 15 mg/kg safely achieved therapeutic levels within 2 hours, maintained by 6 mg/kg daily.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The interaction and interference of preformed metal crowns on magnetic resonance imaging: a scoping review with a systematic methodology.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021

Same author

Artefact or fiction?

British dental journal·2019

Same author

Dental status, visits, and functional ability and dietary intake of elderly in Israel.

Israel journal of health policy research·2018

Same author

Adherence to the Mediterranean diet was positively associated with micronutrient adequacy and negatively associated with dietary energy density among adolescents.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2018

Same author

The demographic and morbidity characteristics of a population receiving food support in Israel.

Israel journal of health policy research·2018

Same author

Texture-modified foods and thickened fluids used in dysphagia: Israeli standardised terminology and definitions.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2018

Area of Science:

Neonatal Medicine
Pharmacology
Clinical Therapeutics

Background:

Neonatal seizures are a common emergency requiring prompt treatment.
Phenobarbitone is a first-line anticonvulsant for neonatal convulsions.
Determining optimal dosing regimens is essential for efficacy and safety.

Purpose of the Study:

To investigate the optimal dosage schedule of phenobarbitone for treating neonatal convulsions.
To establish safe and effective loading and maintenance doses for phenobarbitone in neonates.

Main Methods:

Four groups of infants received different phenobarbitone dosage regimens (intramuscular and intravenous routes).
Phenobarbitone blood levels were monitored regularly.
Gas liquid chromatography was used to determine phenobarbitone concentrations.

Related Experiment Videos

Main Results:

A mean intravenous or intramuscular loading dose of 15 mg/kg achieved therapeutic phenobarbitone levels within 2 hours.
A maintenance dose of 6 mg/kg per day effectively sustained high therapeutic levels.
Different initial dosing strategies showed varying pharmacokinetic profiles.

Conclusions:

A loading dose of approximately 15 mg/kg of phenobarbitone is recommended for rapid achievement of therapeutic levels in neonatal convulsions.
A daily maintenance dose of 6 mg/kg ensures sustained therapeutic concentrations.
This dosing strategy provides a safe and effective treatment for neonatal seizures.