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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antimicrobial therapy for two serious bacterial infections. Enterococcal endocarditis and nosocomial pneumonia

M A Sande

    Archives of Internal Medicine
    |October 25, 1982
    PubMed

    Insights

    New antimicrobial agents are needed to treat difficult enterococcal endocarditis and gram-negative bacillary pneumonia. Current therapies show high relapse rates, toxicity, and mortality, necessitating novel therapeutic approaches.

    Area of Science:

    • Infectious Diseases
    • Pharmacology

    Background:

    • Enterococcal endocarditis and gram-negative bacillary pneumonia are severe infections with limited treatment options.
    • Current therapies often involve dual drug regimens (penicillin/aminoglycoside or beta-lactam/aminoglycoside) with significant drawbacks.

    Purpose of the Study:

    • To highlight the challenges in treating enterococcal endocarditis and gram-negative bacillary pneumonia.
    • To emphasize the urgent need for novel antimicrobial agents with improved safety and efficacy profiles.

    Main Methods:

    • This abstract reviews current treatment strategies and their limitations for specific serious infections.
    • It identifies key challenges, including drug resistance and toxicity, based on existing clinical data.

    Main Results:

    • Enterococcal endocarditis treatment requires combination therapy, with high relapse and toxicity rates even with standard regimens.
    • Gram-negative bacillary pneumonia exhibits high mortality, compounded by overdiagnosis and toxic treatments.

    Conclusions:

    • There is a critical need for the development of new antimicrobial drugs.
    • Novel therapeutic approaches are essential to reduce toxicity and improve outcomes for these challenging infections.

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