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Related Experiment Videos

[Studies on the diffusion of cephapirin into prostatic tissue]

D Adam, A G Hofstetter, G Staehler

    Fortschritte Der Medizin
    |September 15, 1977
    PubMed
    Summary

    Cephapirin (Bristocef) effectively treats prostatic infections. Intravenous administration achieved therapeutic serum and prostatic tissue concentrations in patients with adenoma, indicating its suitability for treating susceptible bacterial infections.

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    Area of Science:

    • Pharmacology and Therapeutics
    • Urology
    • Infectious Diseases

    Context:

    • Prostatic adenoma patients often experience urinary tract infections.
    • Effective antibiotic penetration into prostatic tissue is crucial for treatment.
    • Cephapirin is a cephalosporin antibiotic with activity against Gram-negative rods.

    Purpose:

    • To determine the serum and prostatic tissue concentrations of Cephapirin after intravenous administration.
    • To evaluate the suitability of these concentrations for treating infections in patients with prostatic adenoma.

    Summary:

    • Following intravenous administration of 2 grams of Cephapirin to 13 patients with prostatic adenoma, mean serum concentrations were 50 µg/ml at 30 minutes and 21.5 µg/ml at 60 minutes.
    • Mean prostatic tissue concentrations were 20.8 µg/g.
    • These concentrations suggest Cephapirin is effective against cephapirin-sensitive bacteria in this patient population.

    Impact:

    • Provides pharmacokinetic data for Cephapirin in prostatic tissue.
    • Supports the use of Cephapirin for treating infections in patients with prostatic adenoma.
    • Informs clinical decisions regarding antibiotic selection and dosing for urological infections.

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