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The TM bubble oxygenator: development and clinical application

T Tamiya, S Kitagawa, T Yamashiro

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    |May 1, 1982
    PubMed
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    A new bubble oxygenator was developed to minimize nonphysiological characteristics. Clinical trials in over 200 pediatric patients showed satisfactory results, reducing complications and improving perfusion.

    Area of Science:

    • Biomedical Engineering
    • Cardiopulmonary Bypass Technology

    Background:

    • Traditional bubble oxygenators possess nonphysiological characteristics that can negatively impact patient outcomes.
    • Development efforts focused on addressing these limitations in oxygenator design.

    Purpose of the Study:

    • To develop and evaluate a novel bubble oxygenator designed to reduce nonphysiological characteristics.
    • To assess the clinical performance and safety of the new oxygenator in pediatric patients.

    Main Methods:

    • The oxygenator features reduced priming volume, uniform bubble dispersion, a volume-control system (OCVC), and an integrated microfilter.
    • Structural innovations aimed at improving gas exchange and minimizing blood trauma.
    • Clinical evaluation involved over 200 infants and children undergoing procedures requiring cardiopulmonary bypass.

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    Main Results:

    • The developed oxygenator demonstrated ease of operation during perfusion.
    • Significant reductions in hemolysis and postoperative blood loss were observed.
    • A decrease in microemboli-related complications was noted.
    • Clinical use in over 200 pediatric patients yielded generally satisfactory outcomes.

    Conclusions:

    • The novel bubble oxygenator effectively minimizes nonphysiological characteristics.
    • The device offers improved clinical performance, including reduced complications and blood loss.
    • The oxygenator is suitable for use in pediatric cardiopulmonary bypass procedures.