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Colonometry, cystometry, and evoked potentials in multiple sclerosis

S Haldeman, M Glick, N N Bhatia

    Archives of Neurology
    |November 1, 1982
    PubMed
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    Advanced multiple sclerosis patients exhibit bowel and bladder dysfunction due to neurological lesions above the conus medullaris. Diagnostic tests help document symptoms, locate lesions, and guide treatment for improved patient outcomes.

    Area of Science:

    • Neurology
    • Urology
    • Gastroenterology

    Background:

    • Multiple sclerosis (MS) frequently causes bowel and bladder dysfunction.
    • Accurate diagnosis and lesion localization are crucial for effective management of MS-related symptoms.

    Purpose of the Study:

    • To evaluate the diagnostic utility of colonometry, cystometry, and somatosensory evoked responses in patients with advanced MS.
    • To correlate neurophysiological findings with clinical symptoms of bowel and bladder dysfunction.
    • To determine the location of neurological lesions responsible for these symptoms.

    Main Methods:

    • Utilized colonometry and cystometry to assess bowel and bladder function.
    • Employed somatosensory evoked responses from the posterior tibial nerve to localize neurological lesions.

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  • Compared patient data with neurologically intact controls.

    • Main Results:

    • Patients demonstrated hyperreflexia and reduced filling capacity in both colonometrograms and cystometrograms.
    • Somatosensory evoked responses indicated normal nerve conduction at L-1 but abnormal responses over the scalp.
    • These findings localized neurological lesions to the spinal cord above the conus medullaris.

    Conclusions:

    • The combination of colonometry, cystometry, and somatosensory evoked responses is valuable for diagnosing and localizing neurological lesions in MS patients with bowel and bladder dysfunction.
    • These tests aid in documenting dysfunction and guiding treatment strategies for improved management of MS-related autonomic symptoms.