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[Viral hepatitis B. Seroepidemiological study in Veneto]

R Trivello, M Chiaramonte, R Naccarato

Bollettino Dell'Istituto Sieroterapico Milanese

|May 1, 1982

Summary

Hepatitis B virus (HBV) infection prevalence was 23% in a population survey. Anti-hepatitis B core (anti-HBc) detection is crucial for understanding HBV spread, especially within households.

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Area of Science:

Hepatology
Virology
Epidemiology

Context:

A serological survey was conducted on 3160 individuals without apparent liver disease in the Padova district.
The study population was selected to represent the general population based on age and sex distribution.
This represents a 4% sample of the local resident population.

Purpose:

To determine the seroprevalence of Hepatitis B virus (HBV) infection markers (HBsAg, anti-HBs, anti-HBc).
To analyze the prevalence of HBV infection markers by sex and age.
To evaluate the significance of anti-HBc in seroepidemiological studies and identify transmission patterns.

Summary:

The overall prevalence of HBV infection was 23%.
Hepatitis B surface antigen (HBsAg) positivity was higher in males (3.8%) than females (2.7%), with the highest carrier rate (7.3%) observed in children under 5.

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Anti-hepatitis B core (anti-HBc) antibodies, indicating past or persistent infection, were found in 4.6% of subjects, with higher prevalence in males.

Anti-hepatitis B surface (anti-HBs) antibodies, indicating immunity, showed similar prevalence in both sexes and increased with age.

Impact:

The findings highlight the importance of detecting anti-HBc for accurate HBV seroepidemiological surveys.
The study suggests that household transmission, both vertical and horizontal, plays a significant role in the spread of HBV within the studied population.
Results underscore the need for targeted public health interventions to control HBV transmission.