[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. II. Experimental tumors]

We have investigated the effects on platelet function of culture media from 2 sublines of a benzopyrene-induced murine sarcoma (mFS6). Platelet aggregation was investigated according to Born's method. The cell line with greater "in vivo" invasiveness showed higher aggregating activity and higher increase on ADP-induced aggregation; these effects were inhibited by the preincubation of platelets with Aspirin (0,1 mM). These results suggest the role of platelets in metastasis formation; the possibility to inhibit pharmacologically the interactions between platelets and tumour cells could have important implications from both speculative and practical viewpoints.