[Morphological changes in the hematopoietic organs and the pancreas in experimental exposure to 5-fluorouracil]

Experiments on 30 dogs were performed to study the effect of intraperitoneal irrigation with 5-fluorouracil on the morphology of the pancreas and on the hemopoietic organs. The drug was administered to the abdominal cavity via a catheter in a dose of 5 mg/kg bw for 2, 3 and 5 days. Morphological study revealed no dystrophic or necrobiotic processes in the pancreas, spleen and bone marrow of the animals.