[Role of the lysosomes in altering glucose-6-phosphate dehydrogenase activity in the rat liver during intensive...

Experiments on rats have shown that heavy exercise induces the synthesis in the liver of the key enzyme of the pentosophosphate pathway, glucose-6-phosphate dehydrogenase. The maximum activity is reached 6 and 16 hours after the exercise. Initiation of the protein synthesis is related to activation of hepatocyte lysosomes and their translocation to the nucleus. Administration to the rats of the blockers of lysosomal translocation or an inhibitor of proteolytic activity one hour before swimming completely removes the inducing effect of lysosomes.