[Lymphocyte serotonin receptors: a radioreceptor study]

The radioreceptor method was used to find high affinity, saturable and partially reversible specific binding of 3H-5HT with a gross membrane fraction of human peripheral blood lymphocytes. The Sketchard analysis demonstrated the presence of two types of the binding sites with equilibrium dissociation constants 2 nM and 66 nM. These characteristics are similar to those of 3H-5HT binding with the brain receptors. The results obtained suggest the existence on human lymphocytes of two types of serotonin receptors.