[Effect of cholecystokinin on dopamine metabolism in the rat brain]

The effect of sulfated octapeptide of cholecystokinin (CCK) on dopamine turnover was examined in different parts of the rat brain. It was demonstrated that CCK administered intrapeutoneally in doses of 5, 15 and 30 micrograms/kg significantly increased dopamine turnover in the amygdala, and nucleus accumbeus, without changing dopamine turnover in the midbrain, hypothalamus and striatum. The data suggest that variation in the activity of the mesolimbic dopamine system might be one of the mechanisms by which CCK regulates the animals behavior.