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Nerve growth activities in rat peripheral nerve

P M Richardson, T Ebendal

    Brain Research
    |August 19, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Rat peripheral nerves release at least two nerve growth factors that promote axonal extension. Activity levels change after nerve injury, with some factors decreasing and others increasing in specific nerve regions.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biochemistry

    Background:

    • Nerve regeneration is crucial for recovery after peripheral nerve injury.
    • Nerve growth factor (NGF) is a key regulator of neuronal survival and growth.
    • The existence and nature of other nerve growth-promoting factors are not fully understood.

    Purpose of the Study:

    • To investigate the presence and characteristics of nerve growth-promoting activities in rat sciatic nerves.
    • To differentiate between NGF-like activity and other axonal outgrowth-stimulating factors.
    • To examine how nerve injury and degeneration affect these activities in vivo.

    Main Methods:

    • Culturing chick embryonic ganglia with rat sciatic nerve explants in collagen gels.
    • Assaying neuritic outgrowth in response to nerve fragments.

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  • Utilizing antiserum against 2.5 S mouse NGF to block specific activities.
  • Comparing activity levels in normal, grafted, degenerating, and transected nerves.

    • Main Results:

    • Rat sciatic nerves release at least two distinct agents that stimulate neuritic outgrowth.
    • One agent is similar to nerve growth factor (NGF) and is blocked by anti-NGF antiserum.
    • A second, non-NGF factor also promotes axonal extension, particularly from ciliary ganglia.
    • NGF-like activity is elevated in nerve grafts and degenerating nerves but diminishes in distal segments weeks after injury.
    • Endoneurial NGF-like activity decreases in chronically denervated stumps, while perineurial activity may increase.

    Conclusions:

    • Peripheral nervous tissue contains multiple soluble factors that support axonal outgrowth.
    • Nerve injury and degeneration dynamically alter the levels and distribution of these growth factors.
    • Understanding these factors and their regulation is essential for developing strategies to enhance nerve repair.